Application of titanium materials in the pharmaceutical industry

The pharmaceutical industry is an important industry related to people's physical and mental health, including pharmaceuticals, medical machinery, health materials and other fields, and occupies an important position in the national economy. Titanium is widely used in the pharmaceutical industry because it is non-toxic, harmless and has good compatibility with the human body.

In pharmaceutical production, since the production of pharmaceuticals is inseparable from acids, alkalis, and salts, pharmaceutical equipment is easily damaged by corrosion. The use of steel equipment not only fails to solve the problem of serious equipment corrosion, but also causes a large amount of manpower, material and financial losses, affecting normal production. The use of titanium equipment solves this problem well.

In the production of several major commonly used pharmaceuticals, equipment made of titanium materials has good corrosion resistance and has achieved considerable economic benefits.

Our country often uses the hydrogen chloride conversion method to produce vitamin B1, and the finished product is cyclone dried and separated by two cyclone separators. The medium is thiamine hydrochloride, the pH value is 2.5, the temperature is 110°C, and it is very corrosive. The original drying unit was made of stainless steel. After more than a year of use, the inner wall was corroded and perforated, and the medicine was seriously contaminated.

After using the titanium screw feeder, cyclone separator, vortex flow, hopper and discharge pipe, and titanium lining of the waste gas box, the production qualification rate of vitamin B1 increased from a maximum of 95% to 100%. This equipment has been used for more than 7 years. any corrosion. Titanium cost can be recovered within 3 months.

Vitamin C is made from sorbitol as raw material, fermented by black vinegar bacteria into sorbose, and then fermented by Pseudomonas bacteria. Low concentrations of gulonic acid were obtained. After concentration, it is converted into finished product by hydrogen chloride.

Titanium is relatively resistant to corrosion in high temperature colognic acid. In the production process of this product, titanium tube heat exchangers, titanium DHC-500 butterfly plate settling type automatic slag discharge centrifuge, and GR5 cast impeller are used. No signs of corrosion have been found after years of use.

The main raw material for the chemical synthesis of chloramphenicol (an antibiotic) is methyl dichloroacetate, which contains about 2% chlorene and trichlorethylene. If steel equipment is used during the polishing process, severe corrosion is likely to occur, so titanium is used instead. Equipment remains intact after manufacture.

Procaine hydrochloride for local anesthesia is produced from p-nitrotoluene. The entire production process of oxidation to prepare p-nitrobenzoic acid, acetic acid washing, and mother liquor recovery is highly corrosive. Therefore, the production equipment uses titanium steel composite plate inner cylinder, titanium bubble tube, glacial acetic acid circulation condenser and vapor-liquid separator to solve the problem. Corrosion problem.

Quartzazole (tetraimidazole) is a highly effective anthelmintic for intestinal nematodes. Stainless steel equipment was originally used in the production of this product, but corrosion caused product contamination. Using titanium as water supply pipes and pump water pipes successfully solved the corrosion problem.

Nitrochlorophenol is a specific veterinary drug for the treatment of Fasciola liver flukes in cattle and sheep. It is produced using sulfuric acid, nitric acid, glacial acetic acid and chlorine-containing solutions. The titanium bath stirrer has been used and is currently operating normally. In addition, activated carbon is often used for decolorization in pharmaceutical production. After replacing the stainless steel suction filter with a titanium suction filter, it is still in good condition after 9 years of use.

In the production of foreign brominated amino acids, titanium reactors are used in bromination, separation, salting out, extraction, cooking and other processes. In our country, titanium equipment is also needed to produce malaria drugs using quinoline derivatives, anti-schistosomiasis drugs that are exposed to chloride ions, contraceptives, rheumatism drugs, etc. Others, such as penicillin esterification kettle, saccharification tank, chloramphenicol thin film evaporator, metamizole reactor, metering filter, dimethyl sulfate cooler, liquid filter, etc., can all be made of titanium materials.